Typically, when a standardized treatment or procedure is performed on a biofilm, the biofilm reestablishes itself, and continue to thrive once again. To mitigate this problem, Biofloze, Inc. has developed a novel biofilm-removing technology through collaboration with academic researchers at the University at Buffalo.


Biofloze has developed a compound that aids in biofilm removal. These compounds are surfactants, compounds that can reduce the surface tension between a liquid and a solid, causing the collapse of the biofilm colonies. With sustained release of the biofilm removal compound, over a period of time, the biofilm is weakened, and is ideal for preventing the biofilm from re-establishing itself.

Biodegradable polymers are used – suitable for drug delivery as they undergo hydrolysis in the body (are broken down) to produce their original monomers. These monomers, under normal physiological conditions, are by-products of various metabolic pathways in the body and will not harm the body in any way. Since the body effectively deals with the two monomers, there is minimal systemic toxicity associated with using these polymers for drug delivery or biomaterial applications.

These compounds also do not kill bacteria. They reduce harmful bacteria by inhibiting enzyme activities and neither kills bacteria nor directly inhibits its growth. Hence helping support the balance of healthy flora. The surfactant compounds prevent biofilm formation and further bacterial adherence to the biofilm. This mechanism of action remains the same for all biofilms formed at different anatomical locations as well. Preventing or weakening biofilm attachment is key to reducing biofilm-related infections. A sustained removal of biofilm ensures effective treatment of infection. With the utilization of state-of-the-art nanotechnology (surfactant-encapsulated nanoparticles), along with our existing biofilm removal technology, we are advancing the fight against infection to a different level.


Leads to the collapse of biofilms, enabling antibiotic dosage to be reduced in treating these infections, while also preventing the biofilm reformation.

Low antimicrobial properties of the compound support the balance of healthy flora.

In studies, few side effects have been noted for the surfactants used in our formulation.